GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | trans | rs7045138 | 1 | rs7045138 | chr9:100591463 | NKX6-1 | chr4:85414436-85419387:- | 0.36 | 6.18 | 1.39E-9 | Thyroid hormone levels |
| THCA | trans | rs877636 | 1 | rs705696 | chr12:56480648 | RPS26P11 | chrX:71264259-71264809:+ | 0.52 | 8.99 | 5.79E-18 | Cognitive function |
| THCA | trans | rs7129556 | 1 | rs7129556 | chr11:77300048 | INTS4L1 | chr7:64601603-64694599:+ | -0.53 | -8.02 | 8.41E-15 | Weight loss (gastric bypass surgery) |
| THCA | trans | rs11647589 | 1 | rs7201498 | chr16:20449449 | ZMYND12 | chr1:42896003-42921938:- | 0.26 | 5.97 | 4.74E-9 | Blood metabolite levels |
| THCA | trans | rs4785204 | 1 | rs72798038 | chr16:50149163 | NELF | chr9:140342025-140353786:- | 0.45 | 5.91 | 6.53E-9 | Esophageal cancer (squamous cell) |
| THCA | trans | rs4785204 | 1 | rs72798040 | chr16:50149693 | NELF | chr9:140342025-140353786:- | 0.45 | 5.91 | 6.53E-9 | Esophageal cancer (squamous cell) |
| THCA | trans | rs41266839 | 1 | rs72843784 | chr6:26498758 | ZFP57 | chr6:29640171-29648887:- | 0.93 | 7.82 | 3.48E-14 | Schizophrenia |
| THCA | trans | rs853679 | 1 | rs735765 | chr6:28170297 | BTN3A2 | chr6:26365398-26378546:+ | -0.56 | -10.21 | 2.78E-22 | Depression |
| THCA | trans | rs853679 | 1 | rs735765 | chr6:28170297 | ZFP57 | chr6:29640171-29648887:- | 0.52 | 6.42 | 3.35E-10 | Depression |
| THCA | trans | rs6600671 | 1 | rs7532615 | chr1:121172840 | NBPF14 | chr1:148003643-148346791:- | -0.45 | -10.44 | 3.88E-23 | Hip geometry |
| THCA | trans | rs76329678 | 1 | rs76329678 | chr5:49830286 | LOC647121 | chr1:121260910-121313686:+ | -0.38 | -7.89 | 2.09E-14 | Schizophrenia |
| THCA | trans | rs766432 | 1 | rs766432 | chr2:60719970 | HBG1 | chr11:5269502-5271087:- | -0.46 | -6.75 | 4.24E-11 | Beta thalassemia/hemoglobin E disease;F-cell distribution;Fetal hemoglobin levels;Hemoglobin A2 levels in sickle cell anemia;Sickle cell anemia (haemolysis) |
| THCA | trans | rs1056667 | 1 | rs767471 | chr6:26557854 | ZNF322B | chr9:99957633-99961910:- | 0.58 | 11.4 | 8.92E-27 | Educational attainment |
| THCA | trans | rs853679 | 1 | rs7740487 | chr6:28216486 | BTN3A2 | chr6:26365398-26378546:+ | -0.54 | -10.42 | 4.69E-23 | Depression |
| THCA | trans | rs7824557 | 1 | rs7824557 | chr8:11104111 | SGK223 | chr8:8175259-8239257:- | 0.34 | 6.58 | 1.25E-10 | Retinal vascular caliber |